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In another study using HT22 cells, huperzine A (HupA) + wortmannin treatment stopped the downregulation of p-mTOR, p-Akt, and p-p70s6 kinase under oxidative glutamate toxicity, leading to the conclusion that HupA abrogates oxidative glutamate toxicity in mouse hippocampal cells via the activation of the BDNF/TrkB-dependent PI3K/Akt/mTOR signaling pathway 51

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Their reactivity represents a direct adaptation to environmental cues, and the differences in signal exchange between reactive and nonreactive astrocytes are vital components of the brains immune defense

(Hoboken) 69 , 17511763 (2017)