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Physiological concentrations of melatonin are orders of magnitude lower than the pharmacological doses used in this study

Hernandez-Lopez S, Tkatch T, Perez-Garci E et al (2000) D2 dopamine receptors in striatal medium spiny neurons reduce L-type Ca2 + currents and excitability via a novel PLC[beta]1-IP3-calcineurin-signaling cascade

Liposomal delivery is considered the most effective method because it protects the glutathione in a fatty shell, allowing it to bypass digestion and enter the bloodstream directly