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Daily doses up to 250 mg per day appear safe in cats, and we have occasionally used doses as high as 500 mg per day in cats with no untoward effects

There is possible evidence that PKC, which is stimulated in diabetes via multiple mechanisms activates NAD (P) H oxidase (Amiri et al ., 2002) Natural Defense Against Oxidative Stress and Antioxidants in Diabetes Reactive species can be eliminated by a number of enzymatic and nonenzymatic antioxidant mechanisms

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