Compensatory upregulation of antiapoptotic proteins in response to overexpression of Bcl-XS prevents apoptosis and chemosensitization in AML cell lines
This includes refined carbohydrates (white flour, bread, rice and pasta, pastries, breakfast cereals and cereal bars), sugary drinks, processed snacks, trans fats (such as margarine, spreadable butters and industrial seed oils including rapeseed, corn, safflower, sunflower and soybean oils) and artificial sweeteners (like aspartame used in diet and zero sugar soft drinks)
Its proposed mechanisms are complex and multifaceted, involving interactions with the nitric oxide (NO) system, influence on growth factor expression (like Vascular Endothelial Growth Factor or VEGF), and modulation of cellular pathways related to tissue repair
This enhancement is achieved through the upregulation of miR-30a-3p expression, triggering escalated DNA damage and heightened cisplatin accumulation within the cells